A range of natural extracts standardised in β-caryophyllene from black pepper (Piper nigrum) and cloves (Syzygium aromaticum)
KEY ACTIONS
RAW MATERIALS
CHARACTERISTIC MOLECULES
ACTION
β-Caryophyllene (BCP) selectively binds to the binding site in the named cannabinoid receptor 2 (CB2) leading to the activation of important cellular mechanisms: CB2 receptors are mainly located in the immune system and when activated by their ligands inhibit inflammation and oedema formation, show analgesic effects and mediate protection against hepatic ischaemia/reperfusion injury and reduce inflammation in the gastrointestinal tract.
Recent studies have shown that this molecule significantly reduces oral hyperalgesia, stimulates insulin production, reduces the production of proinflammatory cytokines and reduces intracellular triglyceride concentrations.
BCP is an endocannabinoid that does not bind to the cannabinoid type 1 (CB1) receptor in the central nervous system, so its action does not generate unwanted psychoactive effects.
The consumption of these plants can bring several benefits to the body by providing antioxidant properties, digestive function, regularity of intestinal transit, regularity of gastrointestinal motility and elimination of gases and regular functionality of the cardiovascular system.
RAW MATERIALS
Black pepper berries
Black pepper berries(Piper nigrum L.) are commonly known for the presence of the pungent compound piperine.
However, the oil distilled from these berries is particularly rich in a sesquiterpene that is extremely interesting for its properties: β-caryophyllene.
The hydro-distillation process prevents the piperine from being present in the final essential oil, thus avoiding undesirable effects associated with this other bioactive compound used in other areas.
Black pepper berries
Black pepper berries(Piper nigrum L.) are commonly known for the presence of the pungent compound piperine.
However, the oil distilled from these berries is particularly rich in a sesquiterpene that is extremely interesting for its properties: β-caryophyllene.
The hydro-distillation process prevents the piperine from being present in the final essential oil, thus avoiding undesirable effects associated with this other bioactive compound used in other areas.
Cloves
Clovesare the inflorescence of the species Syzygium aromaticum (L.) Merrill et. Perry (synonym of Eugenia caryophyllata) which belongs to the Myrtaceae family. Cloves are primarily collected as unopened flower buds borne in clusters, which are then dried to produce the familiar commercial spice.
The volatile oils extracted from cloves are produced from the buds by hydro-distillation.
Scientific studies have shown that clove oil can be used as an antibacterial, antifungal and antiseptic agent; it is also good for the digestive function by regulating gastrointestinal motility and gas elimination and is also good for the nose and throat by having a balsamic effect and acting as an antioxidant.
The properties of the oil are due to the presence of numerous monoterpenes and sesquiterpenes, including the bioactive compound β-caryophyllene (BCP).
Cloves
Clovesare the inflorescence of the species Syzygium aromaticum (L.) Merrill et. Perry (synonym of Eugenia caryophyllata) which belongs to the Myrtaceae family. Cloves are primarily collected as unopened flower buds borne in clusters, which are then dried to produce the familiar commercial spice.
The volatile oils extracted from cloves are produced from the buds by hydro-distillation.
Scientific studies have shown that clove oil can be used as an antibacterial, antifungal and antiseptic agent; it is also good for the digestive function by regulating gastrointestinal motility and gas elimination and is also good for the nose and throat by having a balsamic effect and acting as an antioxidant.
The properties of the oil are due to the presence of numerous monoterpenes and sesquiterpenes, including the bioactive compound β-caryophyllene (BCP).
FORMULATIONS
Endophyllene® is available in:
- Endophyllene-P (fluid and powder) made from black pepper berries (Piper nigrum L.)
- Endophyllene-S (fluid and powder) made from cloves (Syzygium aromaticum (L.) Merrill et. Perry) Perry);
Qualitative chemical characterisation is based on gas chromatography combined with mass spectrometry (GC-MS) for the identification and authentication of (E)-β-caryophyllene, while gas chromatography combined with flame ionisation detector (GC-FID) is used for accurate quantification.
Endophyllene® is standardised and titrated in β-caryophyllene and allows accurate dosing in various galenic and nutraceutical forms as it is available in both fluid(80% w/w) and powderform (30% w/w)
INSIGHTS
INSIGHTS ABOUT ENDOPHYLLENE
