{"id":1103,"date":"2022-04-11T17:25:05","date_gmt":"2022-04-11T15:25:05","guid":{"rendered":"https:\/\/biosfered.com\/insights-about-oximacro\/"},"modified":"2022-04-29T15:13:36","modified_gmt":"2022-04-29T13:13:36","slug":"insights-about-oximacro","status":"publish","type":"page","link":"https:\/\/biosfered.com\/en\/insights-about-oximacro\/","title":{"rendered":"INSIGHTS ABOUT OXIMACRO"},"content":{"rendered":"[mk_page_section bg_color=”#ffffff” section_id=”antiossidante” sidebar=”sidebar-1″][vc_column][mk_padding_divider size=”20″][mk_fancy_title color=”#2d2d2d” size=”28″ font_weight=”bold” margin_bottom=”0″ font_family=”none”]Prevention of urinary tract infection with Oximacro\u00ae, a cranberry extract with a high content of A-type Proanthocyanidins (PAC-A). A pre-clinical double-blind controlled study[\/mk_fancy_title][mk_padding_divider size=”20″][\/vc_column][\/mk_page_section][mk_page_section bg_color=”#ffffff” section_id=”antiossidante” sidebar=”sidebar-1″][vc_column][vc_column_text el_class=”testo-nero” css=”.vc_custom_1651146039602{margin-bottom: 0px !important;}”]Purpose<\/b><\/span>: Urinary tract infections (UTIs) are widespread and affect a large portion of the human population. Cranberry juices and extracts have been used for UTI prevention due to their content of bioactive proanthocyanidins (PACs), particularly of the A type (PAC-A). Controversial clinical results obtained with cranberry are often due to a lack of precise determination and authentication of the PAC-A content. This study used Oximacro\u00ae (Biosfered S.r.l., Turin, Italy), a cranberry extract with a high content of PAC-A, to prevent UTIs in female and male volunteers. <\/span><\/p>\n

Materials and Methods:<\/b><\/span> The Oximacro\u00ae PACs content was assayed using the BL-DMAC method, and the dimer and trimer PACs-A and PACs-B percentages were determined via HPLC-ESI-MS\/MS. A balanced group of females (ranging from 19 to over 51 years) and male volunteers (over 51 years) was divided into two groups. The experimental group received 1 capsule containing Oximacro\u00ae (36 mg PACs-A) twice per day (morning and evening) for 7 days, and the placebo group was given the same number of capsules with no PACs. <\/span><\/p>\n

Results:<\/b><\/span> Analysis of Oximacro\u00ae revealed a high total PAC content (372.34 mg\/g \u00b12.3) and a high percentage of PAC-A dimers and trimers (86.72% \u00b11.65). After 7 days of Oximacro\u00ae administration, a significant difference was found between the placebo and Oximacro\u00ae groups for both females (Mann-Whitney U-test = 875; P < .001; N = 60) and males (Mann-Whitney U-test = 24; P = .016; N = 10). When the female and male age ranges were analysed separately, the female age range 31-35 showed only slightly significant differences between the placebo and Oximacro\u00ae groups (Mann-Whitney U-test = 20.5; P = .095; N = 10) , whereas all other female age ranges showed highly significant differences between the placebo and Oximacro\u00ae groups (Mann-Whitney U-test = 25; P = .008; N = 10). Furthermore, CFU\/mL counts from the urocultures showed a significant difference (P < <.001) between the experimental and the placebo groups (SD difference = 51688; df = 34, t = -10.27; Dunn-Sidak Adjusted P< .001, Bonferroni Adjusted P< < .001).<\/span><\/p>\n

Conclusions<\/b><\/span>Careful determination of the total PAC content using the BL-DMAC method and the authentication of PACs-A with mass spectrometry in cranberry extracts are necessary to prepare effective doses for UTI prevention. A dose of 112 mg Oximacro\u00ae containing 36 mg PACs-A was found to be effective in preventing UTIs when used twice per day for 7 days<\/span><\/p>\n

Occhipinti Andrea, Antonio Germano, and Massimo Emilio Maffei. <\/span>“Prevention of urinary tract infection with Oximacro\u00ae, a cranberry extract with a high content of A-type Proanthocyanidins (PAC-A). A pre-clinical double-blind controlled study.” (2016): 2640-2649.<\/span>[\/vc_column_text][\/vc_column][\/mk_page_section]\n","protected":false},"excerpt":{"rendered":"

[mk_page_section bg_color=”#ffffff” section_id=”antiossidante” sidebar=”sidebar-1″][vc_column][mk_padding_divider size=”20″][mk_fancy_title color=”#2d2d2d” size=”28″ font_weight=”bold” margin_bottom=”0″ font_family=”none”]Prevention of urinary tract infection with Oximacro\u00ae, a cranberry extract with a high content of A-type Proanthocyanidins (PAC-A). A pre-clinical double-blind controlled study[\/mk_fancy_title][mk_padding_divider size=”20″][\/vc_column][\/mk_page_section][mk_page_section bg_color=”#ffffff” section_id=”antiossidante” sidebar=”sidebar-1″][vc_column][vc_column_text el_class=”testo-nero” css=”.vc_custom_1651146039602{margin-bottom: 0px !important;}”]Purpose: Urinary tract infections (UTIs) are widespread and affect a large portion of the human population. […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1103","page","type-page","status-publish","hentry"],"yoast_head":"\nINSIGHTS ABOUT OXIMACRO - Biosfered<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biosfered.com\/en\/insights-about-oximacro\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"INSIGHTS ABOUT OXIMACRO - Biosfered\" \/>\n<meta property=\"og:description\" content=\"[mk_page_section bg_color=”#ffffff” section_id=”antiossidante” sidebar=”sidebar-1″][vc_column][mk_padding_divider size=”20″][mk_fancy_title color=”#2d2d2d” size=”28″ font_weight=”bold” margin_bottom=”0″ font_family=”none”]Prevention of urinary tract infection with Oximacro\u00ae, a cranberry extract with a high content of A-type Proanthocyanidins (PAC-A). A pre-clinical double-blind controlled study[\/mk_fancy_title][mk_padding_divider size=”20″][\/vc_column][\/mk_page_section][mk_page_section bg_color=”#ffffff” section_id=”antiossidante” sidebar=”sidebar-1″][vc_column][vc_column_text el_class=”testo-nero” css=”.vc_custom_1651146039602{margin-bottom: 0px !important;}”]Purpose: Urinary tract infections (UTIs) are widespread and affect a large portion of the human population. 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A pre-clinical double-blind controlled study[\/mk_fancy_title][mk_padding_divider size=”20″][\/vc_column][\/mk_page_section][mk_page_section bg_color=”#ffffff” section_id=”antiossidante” sidebar=”sidebar-1″][vc_column][vc_column_text el_class=”testo-nero” css=”.vc_custom_1651146039602{margin-bottom: 0px !important;}”]Purpose: Urinary tract infections (UTIs) are widespread and affect a large portion of the human population. 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