90% standardized β-caryophyllene from cloves (Syzygium aromaticum L.)

Clove, Syzygium aromaticum (L.) Merrill et. Perry, belongs to thes family Myrtaceae. The clove is harvested primarily for the unopened flower buds borne in clusters, which are dried to produce whole clove buds, i.e. the familiar spice of commerce.

Clove volatile oils are produced from buds by idrodistillation.

Studies indicated that clove oil can be used as an antibacterial, antifungal and antiseptic agent.

However, the oil therapeutic properties are due to the presence of numerous monoterpenes and sesquiterpenes, among them the bioactive compound (E)-β-caryophyllene (BCP).

The BCP is a plant volatile compound present in large amounts in the essential oil of many spices, such as cloves. Because of its weak aromatic flavor, BCP is commercially used as a food additive and as a cosmetic product. BCP is a food additive approved by the FDA and is ingested with food daily. BCP is an endo-cannabinoid that does not bind to the type 1 cannabinoid receptor (CB1) in the central nervous system; therefore, it does not produce psychoactive effects.

BCP selectively binds to the CP55,940 binding site (i.e., THC binding site) in the cannabinoid receptor 2 (CB2), leading to cellular activation and anti-inflammatory effects. CB2 receptors are mostly found within the immune system. The CB2 receptor ligands inhibit inflammation and edema formation (Iwamura et al., 2001, J Pharmacol Exp Ther 296: 420- 425), show analgesic effects (Ibrahim et al., 2005, Proc Natl Acad Sci USA 102: 3093-3098) and mediate protection against hepatic ischemia/reperfusion injury (Batkai et al., 2007, FASEB J 21: 1788-1800). In the gastrointestinal tract, the CB2 receptor agonists prevent colitis by reducing inflammation (Kimball et al., 2006, Am J Physiol Gastrointest Liver Physiol 291: G364-371).

BIOS-BCP® DOES NOT CONTAIN EUGENOL. Eugenol was evaluated in 2009 by EFSA. The threshold of concern of this molecule is 1.8 mg/person/day. Biosfered uses a fractionation proprietary method that allows the reduction of eugenol below the threshold limits. This is because eugenol may induce protein phosphorylation in a time dependent manner, which indicates a possible genotoxic effect (double strand breaks), possibly due to oxidative stress (Food and Chemical Toxicology 2018, 118:861-879). For more information on the BCP analysis, see the PipeNig® Facts.

Major advantages of BIOS-BCP®

The qualitative chemical characterization of BIOS-BCP® is based on gas-chromatography coupled to mass spectrometry and GC-FID for the accurate quantification of β-caryophyllene.

  • BIOS-BCP® is titrated in β-caryophyllene, it does not contain eugenol and allows an accurate dosage in both galenic and nutraceutical preparations.
  • BIOS-BCP® is available in liquid form and contains the highest percentage of standardized β-caryophyllene (90%) on the market.

The clove oil is also suitable for digestive function. It regulates the gastrointestinal motility and gas elimination. It is suitable for the wellness of nose and throat. It has a balsamic effect and acts as an antioxidant.

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